Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score.
Perfusion
; 30(6): 457-64, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-25358476
ABSTRACT
BACKGROUND:
Compared to patients without a collateral supply, long-term cardiac mortality is reduced in patients with well-developed coronary collateral circulation (CCC). Cardiovascular risk markers, such as N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitive C-reactive protein (hs-CRP) and high-sensitive cardiac troponin T (hs-cTnT) are independent predictors for cardiovascular mortality.OBJECTIVES:
The main goal of this study was to examine the relationship between CCC and cardiovascular risk markers.METHODS:
We prospectively enrolled 427 stable coronary artery disease patients with chronic total occlusion (mean age 57.5±11.1 years). The patients were divided into two groups, according to their Rentrop scores (a) poorly developed CCC group (Rentrop 0 and 1) and (b) well-developed CCC group (Rentrop 2 and 3). NT-proBNP, hs-CRP, hs-cTnT, uric acid and other biochemical markers were also measured. The SYNTAX score was calculated for all patients.RESULTS:
The patients in the poorly developed CCC group had higher frequencies of diabetes and hypertension (p<0.05 for both). Compared to the well-developed CCC group, the SYNTAX score, Hs-cTnT, hs-CRP, NT-proBNP, uric acid, neutrophil count and mean platelet volume (MPV) values were higher in patients with poorly developed CCC (p<0.05 for all). On multivariate logistic regression analysis, hs-cTnT (ß=0.658, 95% CI=0.589-0.735, p<0.001) and NT-proBNP (ß=0.991, 95% CI=0.987-0.995, p<0.001) as well as hs-CRP and diabetes were independent predictors of CCC.CONCLUSION:
Cardiac risk markers, such as NT-proBNP, hs-cTnT and hs-CRP are independently associated with CCC in stable coronary artery disease with chronic total occlusion.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Doença da Artéria Coronariana
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Proteína C-Reativa
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Circulação Coronária
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Troponina T
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Peptídeo Natriurético Encefálico
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Oclusão Coronária
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article