Effects of Shigella-, Campylobacter- and ETEC-associated diarrhea on childhood growth.
Pediatr Infect Dis J
; 33(10): 1004-9, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25361185
ABSTRACT
BACKGROUND:
Studies examining the etiology-specific effects of diarrheal disease on growth are limited and variable in their analytic methods, making comparisons difficult and priority setting based on these findings challenging. A study by Black et al (Black RE, Brown KH, Becker S. Effects of diarrhea associated with specific enteropathogens on the growth of children in rural Bangladesh. Pediatrics. 1984;331004-1009.) examined the association between Shigella and enterotoxigenic Escherichia coli-related disease and weight gain and linear growth in Bangladeshi children aged 0-5 years. We estimated similar associations in a 2002 cohort of 0- to 6-year-old children in the Peruvian Amazon.METHODS:
Diarrheal surveillence was conducted using household visits 3 times per week. Anthropometry was collected monthly. Mixed-effect models were used to estimate the association between Shigella, ETEC and Campylobacter diarrhea and weight gain in a 2-month period and linear growth over a 9-month period. Diarrheal disease burdens and growth intervals were quantified so as to be as comparable as possible to the original report.RESULTS:
Shigella- and ETEC-associated diarrhea were not associated with diminished weight gain, although the association between ETEC diarrhea and weight gain (-4.5 g/percent of days spent with ETEC, P = 0.098) was twice that of other etiologic agents, as well as similar in magnitude to the original report. Shigella-associated diarrhea was associated with decreased linear growth (0.055 cm less growth/percent days, P = 0.008), also similar to the original study.CONCLUSIONS:
Our findings suggest that associations between enteropathogen-specific diarrheal episodes and growth, particularly Shigella, are comparable across geographic and epidemiological contexts.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por Campylobacter
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Desenvolvimento Infantil
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Diarreia
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Disenteria Bacilar
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Infecções por Escherichia coli
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article