Pericellular proteolysis in cancer.
Genes Dev
; 28(21): 2331-47, 2014 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-25367033
Pericellular proteases have long been associated with cancer invasion and metastasis due to their ability to degrade extracellular matrix components. Recent studies demonstrate that proteases also modulate tumor progression and metastasis through highly regulated and complex processes involving cleavage, processing, or shedding of cell adhesion molecules, growth factors, cytokines, and kinases. In this review, we address how cancer cells, together with their surrounding microenvironment, regulate pericellular proteolysis. We dissect the multitude of mechanisms by which pericellular proteases contribute to cancer progression and discuss how this knowledge can be integrated into therapeutic opportunities.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeo Hidrolases
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Microambiente Tumoral
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Neoplasias
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article