Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning.
Mol Brain
; 7: 78, 2014 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-25373491
ABSTRACT
Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the γ isoform of PI3K (PI3Kγ) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3Kγ in synaptic plasticity and hippocampus-dependent behavioral tasks we overexpressed p110γ, the catalytic subunit of PI3Kγ, in the hippocampal CA1 region. We found that the overexpression of p110γ impairs NMDA receptor-dependent long-term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-term potentiation (LTP) and contextual fear memory were not affected by p110γ overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3Kγ in the hippocampus is required for successful induction of LTD and normal learning.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Classe I de Fosfatidilinositol 3-Quinases
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Aprendizagem Espacial
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Hipocampo
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Plasticidade Neuronal
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article