Expression of WT-1 by the vascular component of acral pseudolymphomatous angiokeratoma of children.
J Cutan Pathol
; 42(1): 50-5, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25376760
ABSTRACT
Acral pseudolymphomatous angiokeratoma of children (APACHE) is a disease comprised by a dense dermal infiltrate of B-lymphocytes and T-lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevus. Currently, most authors consider it to be a type of pseudolymphoma with prominent blood vessels. The latter express CD34 and D2-40, while they lack the expression of Glut-1. The expression of Wilms tumor-1 (WT-1) by APACHE has not yet been studied. In this report, we present a case of APACHE on the right foot of a 4-year-old boy and demonstrate immunoexpression of WT-1 by the blood vessels of the lesion. We also performed serial sections and demonstrated that the WT-1+ vessels with prominent endothelium were D2-40-.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Pseudolinfoma
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Proteínas WT1
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Angioceratoma
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article