Taxane-induced morphea in a patient with CREST syndrome.
Dermatol Reports
; 2(1): e9, 2010 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-25386245
ABSTRACT
The taxanes, docetaxel and paclitaxel, are microtubule stabilizing chemotherapeutic agents that have demonstrated antineoplastic effects in a variety of solid tumors. They have been linked to the development of localized cutaneous sclerosis in some patients. We present a case of docetaxel-induced cutaneous sclerosis of the lower extremities in a patient with pre-existing CREST syndrome. We propose that patients with a history of limited or diffuse systemic sclerosis should be given taxane chemotherapy with caution, as these patients may have an immunological predisposition for the development of drug-induced morphea.
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MEDLINE
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En
Ano de publicação:
2010
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Article