Psoriasis in the elderly: epidemiological and clinical aspects, and evaluation of patients with very late onset psoriasis.
J Eur Acad Dermatol Venereol
; 30(1): 78-82, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-25389080
ABSTRACT
BACKGROUND:
Age of the patients and age of onset of psoriasis may have an impact on the disease. There is little information about psoriasis in elderly patients.OBJECTIVE:
We evaluated epidemiological, clinical aspects, comorbidities and treatments of psoriasis in the elderly (>70 years) patients, and in patients with very late onset psoriasis (onset ≥ 70 years).METHODS:
This observational multicentre non-interventional study of adults with psoriasis was conducted in 29 departments of dermatology in France. A total of 2210 adults with psoriasis were included.RESULTS:
A total of 212 (9.5%) patients were elderly. This group had a higher frequency of females (P = 0.005), a later onset of the disease (P < 0.0001), a lower frequency of familial (P < 0.0001) and plaque psoriasis (P < 0.0001), but higher frequency of guttate and inverse psoriasis (P ≤ 0.005). Hypertension, diabetes, dyslipidaemia, and major cardiovascular events (MACE) were more frequent in this group (P < 0.0001), but not tobacco (P < 0.0001). Systemic and biological therapies were used less frequently in the elderly group (P < 0.0001). Fifty-eight (2.7%) patients had late onset psoriasis. Patients with very late onset psoriasis were more frequently women (P = 0.02) and older (P < 0.0001), among elderly group. They had significantly less frequently familial (P < 0.0001) and plaque psoriasis (P < 0.0001), and were less often on systemic treatment including biological. Frequencies of comorbidities were not statically different but patients with 'early' onset psoriasis have a tendency (P < 0.5) to have higher frequencies of obesity, diabetes, dyslipidaemia, hypertension and MACE.CONCLUSION:
This study highlights phenotypic features of psoriasis in elderly and in very late onset psoriasis. The management of these fragile patients remains poorly codified and needs further investigation.
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Base de dados:
MEDLINE
Assunto principal:
Psoríase
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article