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Whole-exome sequencing reveals defective CYP3A4 variants predictive of paclitaxel dose-limiting neuropathy.
Apellániz-Ruiz, María; Lee, Mi-Young; Sánchez-Barroso, Lara; Gutiérrez-Gutiérrez, Gerardo; Calvo, Isabel; García-Estévez, Laura; Sereno, María; García-Donás, Jesús; Castelo, Beatriz; Guerra, Eva; Leandro-García, Luis J; Cascón, Alberto; Johansson, Inger; Robledo, Mercedes; Ingelman-Sundberg, Magnus; Rodríguez-Antona, Cristina.
Afiliação
  • Apellániz-Ruiz M; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Lee MY; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Sánchez-Barroso L; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Gutiérrez-Gutiérrez G; Neurology Section, Hospital Universitario Infanta Sofía, Madrid, Spain.
  • Calvo I; Medical Oncology Department, Hospital Montepríncipe, Madrid, Spain. Medical Oncology Department, Centro Integral Oncológico Clara Campal, Madrid, Spain.
  • García-Estévez L; Medical Oncology Department, Centro Integral Oncológico Clara Campal, Madrid, Spain.
  • Sereno M; Medical Oncology Department, Hospital Universitario Infanta Sofía, Madrid, Spain.
  • García-Donás J; Gynecological and Genitourinary Tumors Programme Centro Integral Oncologico Clara Campal CIOCC, Madrid, Spain.
  • Castelo B; Medical Oncology Department, Hospital Universitario La Paz, Madrid, Spain.
  • Guerra E; Medical Oncology Department, Hospital Universitario Ramon y Cajal, Madrid, Spain.
  • Leandro-García LJ; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Cascón A; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain.
  • Johansson I; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Robledo M; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain.
  • Ingelman-Sundberg M; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Rodríguez-Antona C; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain. crodriguez@cnio.es.
Clin Cancer Res ; 21(2): 322-8, 2015 Jan 15.
Article em En | MEDLINE | ID: mdl-25398452
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paclitaxel / Doenças do Sistema Nervoso Periférico / Citocromo P-450 CYP3A / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Paclitaxel / Doenças do Sistema Nervoso Periférico / Citocromo P-450 CYP3A / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article