In vitro method of studying the angiotensin activity of chemical compounds.
Bull Exp Biol Med
; 158(1): 115-7, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25403411
ABSTRACT
We developed and tested an experimental model to study in vitro the type 1 angiotensin antagonistic activity of compounds on the isolated portal vein of rats. The reliability of this method was confirmed in tests with saralasin (nonselective antagonist of angiotensin receptors) and losartan (selective antagonist of type 1 angiotensin receptors) in concentrations of 10(-9)-10(-5) mol/liter. The half-maximal inhibitory concentrations (IC50) of these substances were calculated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saralasina
/
Losartan
/
Bloqueadores do Receptor Tipo 1 de Angiotensina II
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article