Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition.

Lamb, Rebecca; Harrison, Hannah; Hulit, James; Smith, Duncan L; Lisanti, Michael P; Sotgia, Federica

Lamb, Rebecca; Harrison, Hannah; Hulit, James; Smith, Duncan L; Lisanti, Michael P; Sotgia, Federica.

Afiliação

Lamb R; The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, University of Manchester. The Breakthrough Breast Cancer Research Unit, Institute of Cancer Sciences, University of Manchester.
Harrison H; The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, University of Manchester. The Breakthrough Breast Cancer Research Unit, Institute of Cancer Sciences, University of Manchester.
Hulit J; The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, University of Manchester. The Breakthrough Breast Cancer Research Unit, Institute of Cancer Sciences, University of Manchester.
Smith DL; The Cancer Research UK Manchester Institute, University of Manchester.
Lisanti MP; The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, University of Manchester. The Breakthrough Breast Cancer Research Unit, Institute of Cancer Sciences, University of Manchester.
Sotgia F; The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, University of Manchester. The Breakthrough Breast Cancer Research Unit, Institute of Cancer Sciences, University of Manchester.

Oncotarget ; 5(22): 11029-37, 2014 Nov 30.

Article em En | MEDLINE | ID: mdl-25415228

Assuntos

Neoplasias da Mama/tratamento farmacológico; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Transportadores de Ácidos Monocarboxílicos/antagonistas & inibidores; Células-Tronco Neoplásicas/efeitos dos fármacos; Simportadores/antagonistas & inibidores; Tiofenos/farmacologia; Uracila/análogos & derivados; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Feminino; Humanos; Células MCF-7; Proteínas Mitocondriais/antagonistas & inibidores; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Terapia de Alvo Molecular; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Proteômica/métodos; Uracila/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Células-Tronco Neoplásicas / Uracila / Neoplasias da Mama / Transportadores de Ácidos Monocarboxílicos / Simportadores / Mitocôndrias Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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