CLC-3 channels in cancer (review).
Oncol Rep
; 33(2): 507-14, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25421907
ABSTRACT
Ion channels are involved in regulating cell proliferation and apoptosis (programed cell death). Since increased cellular proliferation and inhibition of apoptosis are characteristic features of tumorigenesis, targeting ion channels is a promising strategy for treating cancer. CLC-3 is a member of the voltage-gated chloride channel superfamily and is expressed in many cancer cells. In the plasma membrane, CLC-3 functions as a chloride channel and is associated with cell proliferation and apoptosis. CLC-3 is also located in intracellular compartments, contributing to their acidity, which increases sequestration of drugs and leads to chemotherapy drug resistance. In this review, we summarize the recent findings concerning the involvement of CLC-3 in cancer and explore its potential in cancer therapy.
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1
Base de dados:
MEDLINE
Assunto principal:
Canais de Cloreto
/
Neoplasias
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article