In vitro bactericidal activity of aminoglycosides, including the next-generation drug plazomicin, against Brucella spp.
Int J Antimicrob Agents
; 45(1): 76-8, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25459738
ABSTRACT
Plazomicin is a next-generation aminoglycoside with a potentially unique set of clinical characteristics compared with other aminoglycosides. This study assessed the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of plazomicin against 15 clinical isolates as well as three reference strains representing Brucella abortus, Brucella melitensis and Brucella suis. These data were compared with those obtained for six other aminoglycosides and two aminocyclitols. Plazomicin and gentamicin were the only drugs demonstrating bactericidal activity towards two of the three Brucella spp., whilst plazomicin was the only drug exhibiting bactericidal activity against B. suis. This is the first study to assess the bactericidal nature of plazomicin against Brucella spp. in vitro.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Brucella abortus
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Sisomicina
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Brucella melitensis
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Brucella suis
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Viabilidade Microbiana
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Aminoglicosídeos
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Antibacterianos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article