Study on Interaction between 5-Bromo-4-thio-2'-deoxyuridine and human serum albumin by spectroscopy and molecular docking.
Spectrochim Acta A Mol Biomol Spectrosc
; 136 Pt C: 1775-81, 2015 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-25467669
ABSTRACT
The interaction between 5-Bromo-4-thio-2'-deoxyuridine (4-SBrdU) and human serum albumin (HSA) was investigated by the methods of UV-vis absorbance, fluorescence and circular dichroism (CD) spectroscopy and molecular docking under simulative physiological conditions. The results showed that the quenching mechanism of HAS by 4-SBrdU was dynamic fluorescence quenching, hydrophobic interaction was the main intermolecular force based on thermodynamic data, the fluorescence experimental results were in agreement with results obtained by the molecular docking study.
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Base de dados:
MEDLINE
Assunto principal:
Albumina Sérica Humana
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article