Receptor-independent metabolism of platelet-activating factor by myelogenous cells.
FEBS Lett
; 250(2): 341-4, 1989 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-2546802
ABSTRACT
Human neutrophils incorporate and metabolize platelet-activating factor (PAF). We dissociated these events from PAF binding to its receptors. Cells were pretreated with either pronase, a PAF antagonist (L652731), or excess PAF. This reduced PAF receptor numbers by 70 to almost 100% but had no comparable effect upon the neutrophil's ability to metabolize PAF. Furthermore, HL-60 cells efficiently metabolized, but did not specifically bind, PAF. Thus, PAF receptor availability did not correlate with PAF metabolic capacity and we conclude that myelogenous tissues can process this bioactive ligand by a receptor-independent pathway.
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Base de dados:
MEDLINE
Assunto principal:
Fator de Ativação de Plaquetas
/
Glicoproteínas da Membrana de Plaquetas
/
Receptores de Superfície Celular
/
Receptores Acoplados a Proteínas G
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article