Polymerase-mediated high-density incorporation of amphiphilic functionalities into DNA: enhancement of nuclease resistance and stability in human serum.

Fujita, Hiroto; Nakajima, Kohsuke; Kasahara, Yuuya; Ozaki, Hiroaki; Kuwahara, Masayasu

Fujita, Hiroto; Nakajima, Kohsuke; Kasahara, Yuuya; Ozaki, Hiroaki; Kuwahara, Masayasu.

Afiliação

Fujita H; Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Nakajima K; Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Kasahara Y; Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan; National Institute of Biomedical Innovation (NIBIO), 7-6-8 Asagi, Saito, Ibaraki, Osaka 567-0085, Japan.
Ozaki H; Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Kuwahara M; Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan. Electronic address: mkuwa@gunma-u.ac.jp.

Bioorg Med Chem Lett ; 25(2): 333-6, 2015 Jan 15.

Article em En | MEDLINE | ID: mdl-25475204

Assuntos

DNA Polimerase Dirigida por DNA/metabolismo; DNA/química; Oligodesoxirribonucleotídeos/química; Fosfodiesterase I/metabolismo; Soro/química; Humanos; Estrutura Molecular; Especificidade por Substrato

Palavras-chave

Amphiphilic functionality; Biostability; DNA polymerase; High-density incorporation; Modified nucleoside triphosphate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligodesoxirribonucleotídeos / DNA / Soro / Fosfodiesterase I / DNA Polimerase Dirigida por DNA Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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