Silymarin induces cyclin D1 proteasomal degradation via its phosphorylation of threonine-286 in human colorectal cancer cells.

Eo, Hyun Ji; Park, Gwang Hun; Song, Hun Min; Lee, Jin Wook; Kim, Mi Kyoung; Lee, Man Hyo; Lee, Jeong Rak; Koo, Jin Suk; Jeong, Jin Boo

Eo, Hyun Ji; Park, Gwang Hun; Song, Hun Min; Lee, Jin Wook; Kim, Mi Kyoung; Lee, Man Hyo; Lee, Jeong Rak; Koo, Jin Suk; Jeong, Jin Boo.

Afiliação

Eo HJ; Department of Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea.
Park GH; Department of Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea.
Song HM; Department of Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea.
Lee JW; Department of Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea.
Kim MK; Department of Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea.
Lee MH; Gyeongbuk Institute for Bio-industry, Andong 760380, Republic of Korea.
Lee JR; Gyeongbuk Institute for Bio-industry, Andong 760380, Republic of Korea.
Koo JS; Department of Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea; Institute of Agricultural Science and Technology, Andong National University, Andong 760749, Republic of Korea.
Jeong JB; Department of Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea; Institute of Agricultural Science and Technology, Andong National University, Andong 760749, Republic of Korea. Electronic address: jjb0403@anu.ac.kr.

Int Immunopharmacol ; 24(1): 1-6, 2015 Jan.

Article em En | MEDLINE | ID: mdl-25479723

Assuntos

Antineoplásicos/farmacologia; Neoplasias Colorretais/metabolismo; Ciclina D1/metabolismo; Complexo de Endopeptidases do Proteassoma/efeitos dos fármacos; Silybum marianum; Silimarina/farmacologia; Ciclo Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Ciclina D1/genética; Células HCT116; Humanos; Leupeptinas/farmacologia; NF-kappa B/antagonistas & inibidores; Nitrilas/farmacologia; Fosforilação/efeitos dos fármacos; Mutação Puntual/genética; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteólise; Sulfonas/farmacologia; Treonina/genética; Treonina/metabolismo

Palavras-chave

Cancer chemoprevention; Cell growth; Cyclin D1; Human colorectal cancer; Silymarin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Silimarina / Neoplasias Colorretais / Ciclina D1 / Silybum marianum / Complexo de Endopeptidases do Proteassoma / Antineoplásicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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