Hypoxic X-irradiation as an external stimulus for conformational change of oligodeoxynucleotides that possess disulfide bond and regulation of DNAzyme function.

Tanabe, Kazuhito; Okada, Kana; Sugiura, Masaaki; Ito, Takeo; Nishimoto, Sei-Ichi

Tanabe, Kazuhito; Okada, Kana; Sugiura, Masaaki; Ito, Takeo; Nishimoto, Sei-Ichi.

Afiliação

Tanabe K; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan. Electronic address: tanabeka@scl.kyoto-u.ac.jp.
Okada K; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan.
Sugiura M; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan.
Ito T; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan.
Nishimoto S; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan.

Bioorg Med Chem Lett ; 25(2): 310-2, 2015 Jan 15.

Article em En | MEDLINE | ID: mdl-25479773

Assuntos

DNA Catalítico/química; DNA Catalítico/metabolismo; Dissulfetos/química; Hipóxia; Oligodesoxirribonucleotídeos/química; Oligodesoxirribonucleotídeos/efeitos da radiação; Humanos; Conformação de Ácido Nucleico; Oxirredução; Raios X

Palavras-chave

DNAzyme; Disulfide bond; Hypoxic X-irradiation; Oligodeoxynucleotides

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligodesoxirribonucleotídeos / DNA Catalítico / Dissulfetos / Hipóxia Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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