The El Escorial criteria: strengths and weaknesses.
Amyotroph Lateral Scler Frontotemporal Degener
; 16(1-2): 1-7, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25482030
ABSTRACT
The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes.
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Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
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Demência Frontotemporal
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Esclerose Lateral Amiotrófica
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Exame Neurológico
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article