High-efficient synthesis and biological activities of allosamidins.
J Enzyme Inhib Med Chem
; 30(6): 863-6, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-25486024
ABSTRACT
The pseudo-trisaccharide allosamidin 1 is a potent inhibitor of all family-18 chitinases, and it is confirmed to have insecticidal and antifungal activities. But the synthesis of allosamidins is very difficult, and it is a challengeable subject. Allosamidins were synthesized in solid-liquid phase, total solid-phase and total liquid-phase, respectively. Solid-liquid phase method realizes the partial solid-phase synthesis of allosamidins. Total solid-phase method greatly simplifies the purification process. Total liquid-phase method shortens the synthetic steps of allosamidins. The insecticidal and antifungal activities of allosamidins were also reported herein.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilglucosamina
/
Trissacarídeos
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Inibidores Enzimáticos
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Inseticidas
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Antifúngicos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article