Computationally guided design of robust gene circuits.
Methods Mol Biol
; 1244: 167-78, 2015.
Article
em En
| MEDLINE
| ID: mdl-25487097
ABSTRACT
The inability to rationally design and construct circuits that robustly enable complex behaviors is perhaps the most fundamental challenge in synthetic biology. While systems modeling can aid this process and help reduce the space of design strategies, the unavailability and dynamic variability of kinetic parameters limits the utility of such models. Here, we present a general approach that employs an exhaustive enumeration of network architectures to suggest topologies that robustly enable a desired behavior.
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Base de dados:
MEDLINE
Assunto principal:
Biologia Computacional
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article