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The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.
Porcari, Riccardo; Proukakis, Christos; Waudby, Christopher A; Bolognesi, Benedetta; Mangione, P Patrizia; Paton, Jack F S; Mullin, Stephen; Cabrita, Lisa D; Penco, Amanda; Relini, Annalisa; Verona, Guglielmo; Vendruscolo, Michele; Stoppini, Monica; Tartaglia, Gian Gaetano; Camilloni, Carlo; Christodoulou, John; Schapira, Anthony H V; Bellotti, Vittorio.
Afiliação
  • Porcari R; From the Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, and.
  • Proukakis C; the Department of Clinical Neuroscience, Institute of Neurology, University College London, London NW3 2PF, United Kingdom.
  • Waudby CA; the Department of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.
  • Bolognesi B; the Centre for Genomic Regulation and University Pompeu Fabra, 08003 Barcelona, Spain.
  • Mangione PP; From the Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, and the Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100 Pavia, Italy.
  • Paton JF; the Department of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.
  • Mullin S; the Department of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.
  • Cabrita LD; the Department of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.
  • Penco A; the Department of Physics, University of Genoa, 16146 Genoa, Italy.
  • Relini A; the Department of Physics, University of Genoa, 16146 Genoa, Italy.
  • Verona G; From the Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, and the Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100 Pavia, Italy.
  • Vendruscolo M; the Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom, and.
  • Stoppini M; the Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100 Pavia, Italy.
  • Tartaglia GG; the Centre for Genomic Regulation and University Pompeu Fabra, 08003 Barcelona, Spain.
  • Camilloni C; the Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom, and.
  • Christodoulou J; the Department of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom, j.christodoulou@ucl.ac.uk.
  • Schapira AH; the Department of Clinical Neuroscience, Institute of Neurology, University College London, London NW3 2PF, United Kingdom.
  • Bellotti V; From the Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, and the Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100 Pavia, Italy, v.bellotti@ucl.ac.uk.
J Biol Chem ; 290(4): 2395-404, 2015 Jan 23.
Article em En | MEDLINE | ID: mdl-25505181
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alfa-Sinucleína / Mutação Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alfa-Sinucleína / Mutação Idioma: En Ano de publicação: 2015 Tipo de documento: Article