Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications.

van de Werken, Christine; van der Heijden, Godfried W; Eleveld, Cindy; Teeuwssen, Miriam; Albert, Mareike; Baarends, Willy M; Laven, Joop S E; Peters, Antoine H F M; Baart, Esther B

van de Werken, Christine; van der Heijden, Godfried W; Eleveld, Cindy; Teeuwssen, Miriam; Albert, Mareike; Baarends, Willy M; Laven, Joop S E; Peters, Antoine H F M; Baart, Esther B.

Afiliação

van de Werken C; Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherlands.
van der Heijden GW; 1] Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherlands [2] Department of Reproduction and Development, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherla
Eleveld C; Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherlands.
Teeuwssen M; Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherlands.
Albert M; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Baarends WM; Department of Reproduction and Development, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherlands.
Laven JS; Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherlands.
Peters AH; 1] Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland [2] Faculty of Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Baart EB; Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherlands.

Nat Commun ; 5: 5868, 2014 Dec 18.

Article em En | MEDLINE | ID: mdl-25519718

Assuntos

Proteínas Cromossômicas não Histona/genética; Heterocromatina/química; Histonas/genética; Padrões de Herança; Espermatozoides/metabolismo; Animais; Blastocisto/química; Blastocisto/citologia; Blastocisto/metabolismo; Homólogo 5 da Proteína Cromobox; Proteínas Cromossômicas não Histona/metabolismo; Embrião de Mamíferos; Feminino; Fertilização; Fertilização in vitro; Regulação da Expressão Gênica no Desenvolvimento; Heterocromatina/metabolismo; Histonas/metabolismo; Humanos; Masculino; Camundongos; Oócitos/metabolismo; Oócitos/ultraestrutura; Oogênese/genética; Proteínas do Grupo Polycomb/genética; Proteínas do Grupo Polycomb/metabolismo; Especificidade da Espécie; Espermatogênese/genética; Espermatozoides/ultraestrutura; Zigoto/química; Zigoto/citologia; Zigoto/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espermatozoides / Proteínas Cromossômicas não Histona / Heterocromatina / Histonas / Padrões de Herança Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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