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Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.
Li, Jing; Csibi, Alfredo; Yang, Sun; Hoffman, Gregory R; Li, Chenggang; Zhang, Erik; Yu, Jane J; Blenis, John.
Afiliação
  • Li J; Department of Cell Biology, Harvard Medical School, Boston, MA 02115;
  • Csibi A; Department of Cell Biology, Harvard Medical School, Boston, MA 02115;
  • Yang S; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115; and.
  • Hoffman GR; Department of Cell Biology, Harvard Medical School, Boston, MA 02115;
  • Li C; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115; and.
  • Zhang E; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115; and.
  • Yu JJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115; and.
  • Blenis J; Department of Cell Biology, Harvard Medical School, Boston, MA 02115; Sandra and Edward Meyer Cancer Center, Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021 jblenis@med.cornell.edu.
Proc Natl Acad Sci U S A ; 112(1): E21-9, 2015 Jan 06.
Article em En | MEDLINE | ID: mdl-25524627
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Tuberosa / Proteínas de Choque Térmico HSP90 / Complexos Multiproteicos / Serina-Treonina Quinases TOR / Glutaminase Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Tuberosa / Proteínas de Choque Térmico HSP90 / Complexos Multiproteicos / Serina-Treonina Quinases TOR / Glutaminase Idioma: En Ano de publicação: 2015 Tipo de documento: Article