The cellular and molecular basis of direction selectivity of Aδ-LTMRs.
Cell
; 159(7): 1640-51, 2014 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-25525881
ABSTRACT
The perception of touch, including the direction of stimulus movement across the skin, begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the skin. Here, we show that murine Aδ-LTMRs are preferentially tuned to deflection of body hairs in the caudal-to-rostral direction. This tuning property is explained by the finding that Aδ-LTMR lanceolate endings around hair follicles are polarized; they are concentrated on the caudal (downward) side of each hair follicle. The neurotrophic factor BDNF is synthesized in epithelial cells on the caudal, but not rostral, side of hair follicles, in close proximity to Aδ-LTMR lanceolate endings, which express TrkB. Moreover, ablation of BDNF in hair follicle epithelial cells disrupts polarization of Aδ-LTMR lanceolate endings and results in randomization of Aδ-LTMR responses to hair deflection. Thus, BDNF-TrkB signaling directs polarization of Aδ-LTMR lanceolate endings, which underlies direction-selective responsiveness of Aδ-LTMRs to hair deflection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tato
/
Folículo Piloso
/
Gânglios Espinais
/
Mecanorreceptores
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article