Osteopontin mediates an MZF1-TGF-ß1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer.

Weber, C E; Kothari, A N; Wai, P Y; Li, N Y; Driver, J; Zapf, M A C; Franzen, C A; Gupta, G N; Osipo, C; Zlobin, A; Syn, W K; Zhang, J; Kuo, P C; Mi, Z

Weber, C E; Kothari, A N; Wai, P Y; Li, N Y; Driver, J; Zapf, M A C; Franzen, C A; Gupta, G N; Osipo, C; Zlobin, A; Syn, W K; Zhang, J; Kuo, P C; Mi, Z.

Afiliação

Weber CE; Department of Surgery, Loyola University Medical Center, Loyola University Chicago, Maywood, IL, USA.
Kothari AN; The Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
Wai PY; Department of Surgery, Loyola University Medical Center, Loyola University Chicago, Maywood, IL, USA.
Li NY; The Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
Driver J; Department of Surgery, Loyola University Medical Center, Loyola University Chicago, Maywood, IL, USA.
Zapf MA; The Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
Franzen CA; Department of Surgery, Loyola University Medical Center, Loyola University Chicago, Maywood, IL, USA.
Gupta GN; The Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
Osipo C; Department of Surgery, Loyola University Medical Center, Loyola University Chicago, Maywood, IL, USA.
Zlobin A; The Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
Syn WK; Department of Surgery, Loyola University Medical Center, Loyola University Chicago, Maywood, IL, USA.
Zhang J; The Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
Kuo PC; The Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
Mi Z; Department of Urology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.

Oncogene ; 34(37): 4821-33, 2015 Sep 10.

Article em En | MEDLINE | ID: mdl-25531323

Assuntos

Neoplasias da Mama/patologia; Transformação Celular Neoplásica/metabolismo; Fibroblastos/patologia; Células-Tronco Mesenquimais/patologia; Células-Tronco Neoplásicas/patologia; Osteopontina/fisiologia; Animais; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Transformação Celular Neoplásica/genética; Feminino; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Humanos; Fatores de Transcrição Kruppel-Like/genética; Fatores de Transcrição Kruppel-Like/metabolismo; Células MCF-7; Células-Tronco Mesenquimais/metabolismo; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Células-Tronco Neoplásicas/efeitos dos fármacos; Células-Tronco Neoplásicas/metabolismo; Osteopontina/farmacologia; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo; Células Tumorais Cultivadas

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias da Mama / Transformação Celular Neoplásica / Osteopontina / Células-Tronco Mesenquimais / Fibroblastos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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