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Doripenem MICs and ompK36 porin genotypes of sequence type 258, KPC-producing Klebsiella pneumoniae may predict responses to carbapenem-colistin combination therapy among patients with bacteremia.
Shields, Ryan K; Nguyen, M Hong; Potoski, Brian A; Press, Ellen G; Chen, Liang; Kreiswirth, Barry N; Clarke, Lloyd G; Eschenauer, Gregory A; Clancy, Cornelius J.
Afiliação
  • Shields RK; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Nguyen MH; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA mhn5@pitt.edu.
  • Potoski BA; Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Press EG; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Chen L; Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
  • Kreiswirth BN; Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
  • Clarke LG; Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Eschenauer GA; Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Clancy CJ; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA VA Pittsburgh Health System, Pittsburgh, Pennsylvania, USA.
Antimicrob Agents Chemother ; 59(3): 1797-801, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25534733
Treatment failures of a carbapenem-colistin regimen among patients with bacteremia due to sequence type 258 (ST258), KPC-2-producing Klebsiella pneumoniae were significantly more likely if both agents were inactive in vitro, as defined by a colistin MIC of >2 µg/ml and the presence of either a major ompK36 porin mutation (guanine and alanine insertions at amino acids 134 and 135 [ins aa 134-135 GD], IS5 promoter insertion [P = 0.007]) or a doripenem MIC of >8 µg/ml (P = 0.01). Major ompK36 mutations among KPC-K. pneumoniae strains are important determinants of carbapenem-colistin responses in vitro and in vivo.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Carbapenêmicos / Bacteriemia / Porinas / Colistina / Klebsiella pneumoniae Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Carbapenêmicos / Bacteriemia / Porinas / Colistina / Klebsiella pneumoniae Idioma: En Ano de publicação: 2015 Tipo de documento: Article