Fluoroquinolone resistance does not impose a cost on the fitness of Clostridium difficile in vitro.
Antimicrob Agents Chemother
; 59(3): 1794-6, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25534738
ABSTRACT
Point mutations conferring resistance to fluoroquinolones were introduced in the gyr genes of the reference strain Clostridium difficile 630. Only mutants with the substitution Thr-82âIle in GyrA, which characterizes the hypervirulent epidemic clone III/027/NAP1, were resistant to all fluoroquinolones tested. The absence of a fitness cost in vitro for the most frequent mutations detected in resistant clinical isolates suggests that resistance will be maintained even in the absence of antibiotic pressure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Clostridioides difficile
/
Fluoroquinolonas
/
Farmacorresistência Bacteriana
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article