Residues required for phosphorylation of translation initiation factor eIF2&#945; under diverse stress conditions are divergent between yeast and human.

Majumder, Mithu; Mitchell, Daniel; Merkulov, Sergei; Wu, Jing; Guan, Bo-Jhih; Snider, Martin D; Krokowski, Dawid; Yee, Vivien C; Hatzoglou, Maria

Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human.

Majumder, Mithu; Mitchell, Daniel; Merkulov, Sergei; Wu, Jing; Guan, Bo-Jhih; Snider, Martin D; Krokowski, Dawid; Yee, Vivien C; Hatzoglou, Maria.

Afiliação

Majumder M; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States.
Mitchell D; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States.
Merkulov S; Virogene Technology, 11000 Cedar Ave., Cleveland, OH, United States.
Wu J; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States.
Guan BJ; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States.
Snider MD; Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States.
Krokowski D; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States.
Yee VC; Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States. Electronic address: vivien.yee@case.edu.
Hatzoglou M; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States. Electronic address: maria.hatzoglou@case.edu.

Int J Biochem Cell Biol ; 59: 135-41, 2015 Feb.

Article em En | MEDLINE | ID: mdl-25541374

Assuntos

Aminoácidos/metabolismo; Fator de Iniciação 2 em Eucariotos/química; Fator de Iniciação 2 em Eucariotos/metabolismo; Saccharomyces cerevisiae/metabolismo; Estresse Fisiológico; Animais; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Células HEK293; Humanos; Soluções Hipertônicas/farmacologia; Camundongos; Modelos Moleculares; Proteínas Mutantes/metabolismo; Mutação/genética; Estresse Oxidativo/efeitos dos fármacos; Fosforilação/efeitos dos fármacos; Poli I-C/farmacologia; Reprodutibilidade dos Testes; Estresse Fisiológico/efeitos dos fármacos; Relação Estrutura-Atividade

Palavras-chave

Protein kinases; Stress response; Translation initiation; Translational control

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Estresse Fisiológico / Fator de Iniciação 2 em Eucariotos / Aminoácidos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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