N-Bridged 5,6-bicyclic pyridines: Recent applications in central nervous system disorders.
Eur J Med Chem
; 97: 719-31, 2015 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-25542766
ABSTRACT
The search for novel heterobicyclic compounds within the drug-like chemical space continues to be an area of interest in medicinal chemistry. Unsaturated N-bridgehead heterocycles are well represented in marketed drugs for a variety of therapeutic areas, and continue to play an important role in central nervous system (CNS) drug discovery programs. Examples of medicinal chemistry strategies that make use of N-bridged 5,6-bicyclic pyridines are discussed here in this Minireview, which covers the literature from 2010 up to 2014. B1-class imidazopyridines and B3-class pyrazolopyridines have proven to be at the forefront of molecular prototypes that are capable of interacting with disease relevant targets in neurodegeneration and neuropsychiatry.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Doenças do Sistema Nervoso Central
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Descoberta de Drogas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article