A comparative study on the therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on D-GaIN/TNF-&#945;-induced liver damage in Balb/c mice.

Cengiz, Mustafa; Kutlu, H Mehtap; Burukoglu, Dilek D; Ayhanci, Adnan

A comparative study on the therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on D-GaIN/TNF-α-induced liver damage in Balb/c mice.

Cengiz, Mustafa; Kutlu, H Mehtap; Burukoglu, Dilek D; Ayhanci, Adnan.

Afiliação

Cengiz M; Faculty of Science, Department of Biology, Anadolu University, Eskisehir, Turkey. Electronic address: mustafacengizogu@gmail.com.
Kutlu HM; Faculty of Science, Department of Biology, Anadolu University, Eskisehir, Turkey.
Burukoglu DD; Faculty of Medicine, Department of Histology and Embryology, Osmangazi University, Eskisehir, Turkey.
Ayhanci A; Faculty of Arts and Science, Department of Biology, Osmangazi University, Eskisehir, Turkey.

Food Chem Toxicol ; 77: 93-100, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25544390

Assuntos

Galactosamina/efeitos adversos; Lipídeos/química; Fígado/efeitos dos fármacos; Nanopartículas/química; Silimarina/farmacologia; Fator de Necrose Tumoral alfa/efeitos adversos; Animais; Antioxidantes/farmacologia; Sistemas de Liberação de Medicamentos; Fígado/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Tamanho da Partícula; Substâncias Protetoras/farmacologia

Palavras-chave

Balb/c mice; D-GaIN/TNF-α; Hepatoprotectivity; Hepatotoxicity; Silymarin-loaded solid lipid nanoparticle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Silimarina / Fator de Necrose Tumoral alfa / Nanopartículas / Galactosamina / Lipídeos / Fígado Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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