Inactivation of GSK3ß and activation of NF-&#954;B pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma.

Paccez, Juliano D; Duncan, Kristal; Vava, Akhona; Correa, Ricardo G; Libermann, Towia A; Parker, M Iqbal; Zerbini, Luiz F

Inactivation of GSK3ß and activation of NF-κB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma.

Paccez, Juliano D; Duncan, Kristal; Vava, Akhona; Correa, Ricardo G; Libermann, Towia A; Parker, M Iqbal; Zerbini, Luiz F.

Afiliação

Paccez JD; International Centre for Genetic Engineering and Biotechnology, Cape Town 7925, South Africa Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa.
Duncan K; International Centre for Genetic Engineering and Biotechnology, Cape Town 7925, South Africa Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa.
Vava A; International Centre for Genetic Engineering and Biotechnology, Cape Town 7925, South Africa Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa.
Correa RG; Sanford-Burnham Medical Research Institute, La Jolla, CA 92037.
Libermann TA; BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115.
Parker MI; International Centre for Genetic Engineering and Biotechnology, Cape Town 7925, South Africa Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa.
Zerbini LF; International Centre for Genetic Engineering and Biotechnology, Cape Town 7925, South Africa Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa luiz.zerbini@icgeb.org.

Mol Biol Cell ; 26(5): 821-31, 2015 Mar 01.

Article em En | MEDLINE | ID: mdl-25568334

Assuntos

Carcinogênese/metabolismo; Carcinoma de Células Escamosas/metabolismo; Neoplasias Esofágicas/metabolismo; Quinase 3 da Glicogênio Sintase/metabolismo; NF-kappa B/metabolismo; Proteínas Proto-Oncogênicas/metabolismo; Receptores Proteína Tirosina Quinases/metabolismo; Transdução de Sinais; Animais; Carcinogênese/genética; Carcinoma de Células Escamosas/enzimologia; Carcinoma de Células Escamosas/etiologia; Carcinoma de Células Escamosas/genética; Linhagem Celular Tumoral; Neoplasias Esofágicas/enzimologia; Neoplasias Esofágicas/etiologia; Neoplasias Esofágicas/genética; Carcinoma de Células Escamosas do Esôfago; Regulação Neoplásica da Expressão Gênica; Quinase 3 da Glicogênio Sintase/antagonistas & inibidores; Glicogênio Sintase Quinase 3 beta; Humanos; Masculino; Camundongos; Camundongos Nus; Proteínas Proto-Oncogênicas/genética; Receptores Proteína Tirosina Quinases/genética; Receptor Tirosina Quinase Axl

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Transdução de Sinais / NF-kappa B / Proteínas Proto-Oncogênicas / Receptores Proteína Tirosina Quinases / Quinase 3 da Glicogênio Sintase / Carcinogênese Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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