Functionalized cyclopentenes through a tandem NHC-catalyzed dynamic kinetic resolution and ambient temperature decarboxylation: mechanistic insight and synthetic application.
Chem Commun (Camb)
; 51(13): 2690-3, 2015 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-25575249
ABSTRACT
An unusual room temperature ß-lactone decarboxylation facilitated a five-step enantioselective formal synthesis of the cyclopentane core of an estrogen receptor ß-agonist. A computational study probed the underlying factors facilitating unprecedented, rapid decarboxylation. Aryl substitution promotes faster reaction in the retro-[2+2] as a result of conjugative stabilization with the forming olefin. Additionally, the configuration of the α-ester in these fused ß-lactones leads to differential decarboxylation rates.
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Base de dados:
MEDLINE
Assunto principal:
Temperatura
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Ciclopentanos
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Simulação de Dinâmica Molecular
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Compostos Heterocíclicos
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Metano
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article