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Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.
Zhong, Yiming; Dong, Shuai; Strattan, Ethan; Ren, Li; Butchar, Jonathan P; Thornton, Kelsey; Mishra, Anjali; Porcu, Pierluigi; Bradshaw, J Michael; Bisconte, Angelina; Owens, Timothy D; Verner, Erik; Brameld, Ken A; Funk, Jens Oliver; Hill, Ronald J; Johnson, Amy J; Dubovsky, Jason A.
Afiliação
  • Zhong Y; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210.
  • Dong S; the Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Ohio State University, Columbus, Ohio 43210, and.
  • Strattan E; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210.
  • Ren L; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210.
  • Butchar JP; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210.
  • Thornton K; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210.
  • Mishra A; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210.
  • Porcu P; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210.
  • Bradshaw JM; Principia Biopharma, South San Francisco, California 94080.
  • Bisconte A; Principia Biopharma, South San Francisco, California 94080.
  • Owens TD; Principia Biopharma, South San Francisco, California 94080.
  • Verner E; Principia Biopharma, South San Francisco, California 94080.
  • Brameld KA; Principia Biopharma, South San Francisco, California 94080.
  • Funk JO; Principia Biopharma, South San Francisco, California 94080.
  • Hill RJ; Principia Biopharma, South San Francisco, California 94080 ron.hill@principiabio.com.
  • Johnson AJ; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210.
  • Dubovsky JA; From the Division of Hematology, College of Medicine, Ohio State University, Columbus, Ohio 43210, jason.dubovsky@nationwidechildrens.org.
J Biol Chem ; 290(10): 5960-78, 2015 Mar 06.
Article em En | MEDLINE | ID: mdl-25593320
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Proteínas Tirosina Quinases / Linfócitos T / Inibidores de Proteínas Quinases Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Proteínas Tirosina Quinases / Linfócitos T / Inibidores de Proteínas Quinases Idioma: En Ano de publicação: 2015 Tipo de documento: Article