Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort.
Osteoarthritis Cartilage
; 23(4): 544-9, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25596322
ABSTRACT
OBJECTIVE:
To identify and validate previously established phenotypes of knee osteoarthritis (OA) based on similarities in clinical patient characteristics.METHODS:
Knee OA patients (N = 551) from the Amsterdam OA (AMS-OA) cohort provided data. Four clinical patient characteristics were assessed upper leg muscle strength, body mass index (BMI), radiographic severity (Kellgren/Lawrence [KL] grade), and depressive mood (the Hospital Anxiety and Depression Scale [HADS] questionnaire). Cluster analysis was performed to identify the optimal number of phenotypes. Differences in clinical characteristics between the phenotypes were analyzed with ANOVA.RESULTS:
Cluster analysis identified five phenotypes of knee OA patients "minimal joint disease phenotype", "strong muscle strength phenotype", "severe radiographic OA phenotype", "obese phenotype", and "depressive mood phenotype".CONCLUSIONS:
Among patients with knee OA, five phenotypes were identified based on four clinical characteristics. To a high degree, the results are a replication of earlier findings in the OA Initiative, indicating that these five phenotypes seem a stable, valid, and clinically relevant finding.Palavras-chave
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Assunto principal:
Fenótipo
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Osteoartrite do Joelho
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Depressão
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Força Muscular
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Articulação do Joelho
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Obesidade
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article