Synthesis and photophysical characterization of quasi push-pull dicyanodibenzodioxins and their anti-tumor activity against glioma cell line C6.
Bioorg Med Chem Lett
; 25(4): 753-7, 2015 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-25597009
ABSTRACT
Dibenzodioxins bearing multiple electron withdrawing groups were synthesized using a simple one-step methodology including examples of molecules possessing electron acceptor groups in both ends. As a consequence internal charge delocalization occurs and the optical spectra are found to be bathochromically shifted compared to similar examples known thus far. A theoretical analysis of the molecular orbitals reveals the origin of the peaks in the dibenzodioxin optical spectra. Select examples exhibit in vitro neuro-cytotoxicity against glioma cell line C6, a finding which enhances existing knowledge about the pharmacologically relevant structural motifs in dibenzodioxins.
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MEDLINE
Assunto principal:
Dioxinas
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Glioma
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article