Characterization of a new human plasma cell leukemia cell line UHKT-944.
Eur J Haematol
; 95(4): 352-60, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-25600340
ABSTRACT
OBJECTIVE:
A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia.RESULTS:
The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-kappa. VH3-9 region of IgVH genes was rearranged and somatically hypermutated. The UHKT-944 cells were found to be negative for most of tested B-cell, T-cell, and myeloid markers. According to cytogenetic analysis, the cells were classified as near tetraploid with several numerical and structural abnormalities including the t(14;20) involving IgH locus.CONCLUSION:
The established permanent plasma cell leukemia cell line is a suitable model for the study of cellular and molecular mechanisms of pathogenesis of this rare malignant disease.Palavras-chave
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1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Plasmocitária
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article