NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release.
J Neurosci
; 35(3): 1038-42, 2015 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-25609620
ABSTRACT
A neuropeptide (NLP-12) and its receptor (CKR-2) potentiate tonic and evoked ACh release at Caenorhabditis elegans neuromuscular junctions. Increased evoked release is mediated by a presynaptic pathway (egl-30 Gαq and egl-8 PLCß) that produces DAG, and by DAG binding to short and long UNC-13 proteins. Potentiation of tonic ACh release persists in mutants deficient for egl-30 Gαq and egl-8 PLCß and requires DAG binding to UNC-13L (but not UNC-13S). Thus, NLP-12 adjusts tonic and evoked release by distinct mechanisms.
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MEDLINE
Assunto principal:
Neuropeptídeos
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Acetilcolina
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Proteínas de Transporte
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Proteínas de Caenorhabditis elegans
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Junção Neuromuscular
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article