Subunit disassembly and inhibition of TNF&#945; by a semi-synthetic bicyclic peptide.

Luzi, Stefan; Kondo, Yasushi; Bernard, Elise; Stadler, Lukas K J; Vaysburd, Marina; Winter, Greg; Holliger, Philipp

Subunit disassembly and inhibition of TNFα by a semi-synthetic bicyclic peptide.

Luzi, Stefan; Kondo, Yasushi; Bernard, Elise; Stadler, Lukas K J; Vaysburd, Marina; Winter, Greg; Holliger, Philipp.

Afiliação

Luzi S; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Kondo Y; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Bernard E; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Stadler LK; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Vaysburd M; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Winter G; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Holliger P; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK ph1@mrc-lmb.cam.ac.uk.

Protein Eng Des Sel ; 28(2): 45-52, 2015 Feb.

Article em En | MEDLINE | ID: mdl-25614525

Assuntos

Epitopos; Peptídeos Cíclicos; Fator de Necrose Tumoral alfa; Linhagem Celular; Cristalografia por Raios X; Epitopos/química; Epitopos/metabolismo; Humanos; Peptídeos Cíclicos/química; Peptídeos Cíclicos/farmacologia; Estrutura Secundária de Proteína; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Fator de Necrose Tumoral alfa/química; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

TNF; bicyclic peptide; phage display; protein engineering

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Fator de Necrose Tumoral alfa / Epitopos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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