HPC-A dose prediction on the optia® cell separator based on a benchmark CE2 collection efficiency: Promoting clinical efficiency, minimizing toxicity, and allowing quality control.
J Clin Apher
; 30(6): 321-8, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-25619791
ABSTRACT
It has been shown that it is possible to predict the CD 34+ hematopoietic progenitor cell dose from collection procedures on TerumoBCT COBE Spectra® cell separator platform using simple variables available at the start of the procedure. In this article, we demonstrate that this can be done simply and reliably using TerumoBCT Spectra Optia® ("Optia") cell separator platform with a very close correlation between predicted and actual results (correlation coefficient 0.956). This knowledge can be used to optimize apheresis sessions and to minimize harmful effects and costs. In addition, we have shown differences in collection efficiency between healthy donors and cancer patients undergoing autologous donation. Finally, we have shown a small but significant improvement in collection efficiency for the Optia platform compared with the COBE Spectra platform.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Remoção de Componentes Sanguíneos
/
Células-Tronco Hematopoéticas
/
Separação Celular
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article