Real-world effectiveness of varenicline versus nicotine replacement therapy in patients with and without psychiatric disorders.
J Addict Med
; 9(3): 169-76, 2015.
Article
em En
| MEDLINE
| ID: mdl-25622124
ABSTRACT
OBJECTIVE:
To compare the effectiveness and safety of varenicline with nicotine replacement therapy (NRT) among smokers with or without psychiatric disorders attending a storefront smoking cessation clinic in an urban addiction and mental health academic health science center.METHODS:
A retrospective chart review was conducted to compare treatment outcomes, demographics, and clinical characteristics for adult smokers prescribed varenicline (n = 98) or NRT (n = 98) between 2007 and 2010. Subjects were matched 11 on age, sex, and year of initial assessment.RESULTS:
End-of-treatment quit rates were almost twice as high among those prescribed varenicline (33.7%) versus NRT (18.4%) (RR = 1.83, 95% CI = 1.11-3.03, P = 0.02). After adjusting for several baseline and treatment characteristics, varenicline was still significantly more effective than NRT (ARR = 1.71, 95% CI = 1.05-2.79, P = 0.03). History of psychiatric disorder (excluding substance use disorders) and treatment duration were also independent predictors of end-of-treatment quit rates. Nausea was more commonly reported among those using varenicline (13.3% vs 3.1%, P = 0.009). No single neuropsychiatric adverse effect significantly differed between groups; however, overall reporting of any neuropsychiatric effect was somewhat higher in the varenicline group (31.6% vs 20.4%, P = 0.07). There was one incident of suicidal ideation in each medication group.CONCLUSIONS:
Varenicline seems to be more effective than NRT and as safe in real-world settings among patients with and without a history of psychiatric disorder.
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Base de dados:
MEDLINE
Assunto principal:
Abandono do Hábito de Fumar
/
Agonistas Nicotínicos
/
Dispositivos para o Abandono do Uso de Tabaco
/
Vareniclina
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Transtornos Mentais
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article