Selenocysteine incorporation: A trump card in the game of mRNA decay.
Biochimie
; 114: 97-101, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25622574
ABSTRACT
The incorporation of the 21st amino acid, selenocysteine (Sec), occurs on mRNAs that harbor in-frame stop codons because the Sec-tRNA(Sec) recognizes a UGA codon. This sets up an intriguing interplay between translation elongation, translation termination and the complex machinery that marks mRNAs that contain premature termination codons for degradation, leading to nonsense mediated mRNA decay (NMD). In this review we discuss the intricate and complex relationship between this key quality control mechanism and the process of Sec incorporation in mammals.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Selenocisteína
/
Degradação do RNAm Mediada por Códon sem Sentido
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article