Plumbagin Inhibits Prostate Carcinogenesis in Intact and Castrated PTEN Knockout Mice via Targeting PKCÎµ, Stat3, and Epithelial-to-Mesenchymal Transition Markers.

Hafeez, Bilal Bin; Fischer, Joseph W; Singh, Ashok; Zhong, Weixiong; Mustafa, Ala; Meske, Louise; Sheikhani, Mohammad Ozair; Verma, Ajit Kumar

Hafeez, Bilal Bin; Fischer, Joseph W; Singh, Ashok; Zhong, Weixiong; Mustafa, Ala; Meske, Louise; Sheikhani, Mohammad Ozair; Verma, Ajit Kumar.

Afiliação

Hafeez BB; Department of Human Oncology, Wisconsin Institute for Medical Research, Paul Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin. hafeez@humonc.wisc.edu.
Fischer JW; Department of Human Oncology, Wisconsin Institute for Medical Research, Paul Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Singh A; Department of Human Oncology, Wisconsin Institute for Medical Research, Paul Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Zhong W; Department of Pathology, Wisconsin Institute for Medical Research, Paul Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Mustafa A; Department of Human Oncology, Wisconsin Institute for Medical Research, Paul Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Meske L; Department of Human Oncology, Wisconsin Institute for Medical Research, Paul Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Sheikhani MO; Department of Human Oncology, Wisconsin Institute for Medical Research, Paul Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Verma AK; Department of Human Oncology, Wisconsin Institute for Medical Research, Paul Carbone Comprehensive Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

Cancer Prev Res (Phila) ; 8(5): 375-86, 2015 May.

Article em En | MEDLINE | ID: mdl-25627799

Assuntos

Adenocarcinoma/prevenção & controle; Antineoplásicos Fitogênicos/farmacologia; Carcinogênese/efeitos dos fármacos; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Naftoquinonas/farmacologia; Neoplasias da Próstata/prevenção & controle; Adenocarcinoma/patologia; Animais; Antineoplásicos Fitogênicos/uso terapêutico; Biomarcadores/metabolismo; Carcinogênese/genética; Carcinogênese/metabolismo; Transição Epitelial-Mesenquimal/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Naftoquinonas/uso terapêutico; Orquiectomia; PTEN Fosfo-Hidrolase/genética; Neoplasia Prostática Intraepitelial/tratamento farmacológico; Neoplasia Prostática Intraepitelial/patologia; Neoplasias da Próstata/patologia; Proteína Quinase C-épsilon/metabolismo; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma / Naftoquinonas / Transição Epitelial-Mesenquimal / Carcinogênese / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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