Metabolism and metabolites of polychlorinated biphenyls.
Crit Rev Toxicol
; 45(3): 245-72, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25629923
ABSTRACT
Abstract The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable metabolites are formed in the processes of biotransformation in biota in general, and in humans in particular. The aim of this document is to provide an overview of PCB metabolism, and to identify the metabolites of concern and their occurrence. Emphasis is given to mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood. Potential intracellular targets and health risks are also discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bifenilos Policlorados
/
Poluentes Ambientais
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article