A rare ancestral HLA-DRB1(∗)15:01ÌDQB1(∗)02:01 haplotype and its reversion in the same Western European family.
Hum Immunol
; 76(2-3): 124-8, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25636575
ABSTRACT
The HLA-DR and -DQ loci are close neighbors on chromosome 6 that are highly linked. Many common associations between HLA-DR and DQ-alleles are known, normally transmitted as HLA-DRÌDQ haplotypes from one generation to another. Reports of very recent genetic rearrangements between HLA-DR and -DQ are rarely found in the literature. In Europeans haplotypes containing DRB1(∗)1501, DQB1(∗)0201, and DQA1(∗)0501 have not been reported before. We report the finding of the rare HLA haplotype A(∗)2402ÌC(∗)0702ÌB(∗)0702ÌMICA(∗)00801ÌDRB5(∗)0101ÌDRB1(∗)1501ÌDQA1(∗)0501ÌDQB1(∗)0201ÌDPB1(∗)0401 in a German stem cell donor with East Frisian ancestry. Our observation suggests a rare ancestral recombination between the DR and DQ loci. In order to investigate this haplotype, we typed 50/74 members of the family encompassing four generations for HLA classes I and II by serological and molecular methods. The rare haplotype was identified in 12 heterozygous carriers. Furthermore, we identified and further characterized a putative crossing over event resulting in its reversion to a common haplotype.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 6
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Cadeias beta de HLA-DQ
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Cadeias HLA-DRB1
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article