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Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
Liu, Hong; Irwanto, Astrid; Fu, Xi'an; Yu, Gongqi; Yu, Yongxiang; Sun, Yonghu; Wang, Chuan; Wang, Zhenzhen; Okada, Yukinori; Low, Huiqi; Li, Yi; Liany, Herty; Chen, Mingfei; Bao, Fangfang; Li, Jinghui; You, Jiabao; Zhang, Qilin; Liu, Jian; Chu, Tongsheng; Andiappan, Anand Kumar; Wang, Na; Niu, Guiye; Liu, Dianchang; Yu, Xiulu; Zhang, Lin; Tian, Hongqing; Zhou, Guizhi; Rotzschke, Olaf; Chen, Shumin; Zhang, Xuejun; Liu, Jianjun; Zhang, Furen.
Afiliação
  • Liu H; 1] Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China. [2] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [3] School of Medicine, Shandong University, Jinan, China. [4] Shandong Provincial Key Laborator
  • Irwanto A; 1] Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore. [2] Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  • Fu X; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Yu G; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Yu Y; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Sun Y; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Wang C; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Wang Z; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Okada Y; 1] Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [3] Program in Medical and Population Genetics, Broad Ins
  • Low H; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore.
  • Li Y; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore.
  • Liany H; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore.
  • Chen M; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Bao F; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Li J; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • You J; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Zhang Q; School of Medicine, Shandong University, Jinan, China.
  • Liu J; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Chu T; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Andiappan AK; Singapore Immunology Network, Singapore.
  • Wang N; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Niu G; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Liu D; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Yu X; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Zhang L; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Tian H; 1] Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China. [2] National Clinical Key Project of Dermatology and Venereology, Jinan, China.
  • Zhou G; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Rotzschke O; Singapore Immunology Network, Singapore.
  • Chen S; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China.
  • Zhang X; 1] Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei, China. [2] Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education and Anhui Province, Hefei, China.
  • Liu J; 1] Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore. [2] Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  • Zhang F; 1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] School of Medicine, Shandong University, Jinan, China. [3] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China. [4] National Clinical Key Project of Dermatolog
Nat Genet ; 47(3): 267-71, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25642632
Genome-wide association studies (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, providing biological insight into the role of host genetic factors in mycobacterial infection. However, the identified loci only partially explain disease heritability, and additional genetic risk factors remain to be discovered. We performed a 3-stage GWAS of leprosy in the Chinese population using 8,313 cases and 16,017 controls. Besides confirming all previously published loci, we discovered six new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy. A systematic evaluation of pleiotropic effects demonstrated a high tendency for leprosy susceptibility loci to show association with autoimmunity and inflammatory diseases. Further analysis suggests that molecular sensing of infection might have a similar pathogenic role across these diseases, whereas immune responses have discordant roles in infectious and inflammatory diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Loci Gênicos / Hanseníase Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Loci Gênicos / Hanseníase Idioma: En Ano de publicação: 2015 Tipo de documento: Article