Mechanisms of gene duplication and amplification.
Cold Spring Harb Perspect Biol
; 7(2): a016592, 2015 Feb 02.
Article
em En
| MEDLINE
| ID: mdl-25646380
ABSTRACT
Changes in gene copy number are among the most frequent mutational events in all genomes and were among the mutations for which a physical basis was first known. Yet mechanisms of gene duplication remain uncertain because formation rates are difficult to measure and mechanisms may vary with position in a genome. Duplications are compared here to deletions, which seem formally similar but can arise at very different rates by distinct mechanisms. Methods of assessing duplication rates and dependencies are described with several proposed formation mechanisms. Emphasis is placed on duplications formed in extensively studied experimental situations. Duplications studied in microbes are compared with those observed in metazoan cells, specifically those in genomes of cancer cells. Duplications, and especially their derived amplifications, are suggested to form by multistep processes often under positive selection for increased copy number.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Amplificação de Genes
/
Duplicação Gênica
/
Modelos Genéticos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article