HLA-B alleles B*15:01 and B*15:02: opposite association with hepatitis C virus infection in Chinese voluntary blood donors.
Intervirology
; 58(2): 80-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-25677350
ABSTRACT
BACKGROUND:
Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent in China, where the HCV prevalence is higher than the global average.METHODS:
In this study, 426 HCV-infected and 709 uninfected blood donors were analyzed, among whom the HLA alleles were sequenced using a high-resolution genotyping method.RESULTS:
At the 2-digit level, none of the alleles showed a statistical difference between the HCV-infected and uninfected groups. However, at the 4-digit level, the HLA-B alleles B*1501 and B*1502 showed an opposite association with HCV infection, i.e. B*1501 was significantly higher in the HCV-infected group (odds ratio, OR = 1.561, p = 0.010), while B*1502 was significantly higher in the uninfected group (OR = 0.778, p = 0.016). We also identified a higher frequency of B*1302 in the HCV-infected group (OR = 1.515, p = 0.009) and a higher frequency of B*0705 in the uninfected group (OR = 0.299, p = 0.001).CONCLUSIONS:
The frequencies of four HLA alleles, B*0705, B*1302, B*1501, and B*1502, were found to be significantly different between the HCV-infected and uninfected blood donors in China, revealing an inverse relation of B*1501 and B*1502 with HCV infection. This finding suggests that the ethnic genetic variations of HLA may greatly affect the host immune responses against HCV.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Genes MHC Classe I
/
Hepatite C Crônica
/
Antígeno HLA-B15
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article