Synthesis and evaluation of new &#945;-methylene-Î³-lactone carbamates with NO production inhibitory effects in lipopolysaccharide-induced RAW 264.7 macrophages.

Shao, Wen-Hao; Chen, Bing-Yang; Cheng, Xiang-Rong; Yuan, Hu; Chen, Hao; Chang, Wan-Lin; Ye, Ji; Lin, Shan; Sun, Qing-Yan; Zhang, Wei-Dong

Synthesis and evaluation of new α-methylene-Î³-lactone carbamates with NO production inhibitory effects in lipopolysaccharide-induced RAW 264.7 macrophages.

Shao, Wen-Hao; Chen, Bing-Yang; Cheng, Xiang-Rong; Yuan, Hu; Chen, Hao; Chang, Wan-Lin; Ye, Ji; Lin, Shan; Sun, Qing-Yan; Zhang, Wei-Dong.

Afiliação

Shao WH; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Chen BY; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Cheng XR; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Yuan H; Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.
Chen H; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Chang WL; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Ye J; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Lin S; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Sun QY; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China. Electronic address: sqy_2000@163.com.
Zhang WD; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China. Electronic address: wdzhangy@hotmail.com.

Eur J Med Chem ; 93: 274-80, 2015 Mar 26.

Article em En | MEDLINE | ID: mdl-25703295

Assuntos

Carbamatos/química; Carbamatos/farmacologia; Lactonas/química; Lipopolissacarídeos/efeitos adversos; Macrófagos/efeitos dos fármacos; Óxido Nítrico/biossíntese; Animais; Anti-Inflamatórios/síntese química; Anti-Inflamatórios/química; Anti-Inflamatórios/farmacologia; Carbamatos/síntese química; Técnicas de Química Sintética; Camundongos; Células RAW 264.7

Palavras-chave

Carbamate; Cytotoxicity; NO inhibitory effect; α-Methylene-Î³-lactone

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbamatos / Lipopolissacarídeos / Lactonas / Macrófagos / Óxido Nítrico Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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