Enolase is regulated by Liver X Receptors.
Steroids
; 99(Pt B): 266-71, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25708389
ABSTRACT
Enolase is a glycolytic enzyme known to inhibit cholesteryl ester hydrolases (CEHs). Cholesteryl ester loading of macrophages, as occurs during atherosclerosis, is accompanied by increased Enolase protein and activity. Here, we describe that J774 macrophages treated with LXR agonists exhibit reduced Enolase transcript and protein abundance. Moreover, we show that this reduction is further potentiated by activation of the LXR/RXR heterodimer with the RXR ligand 9-cis retinoic acid. Enolase levels are also reduced in vivo following activation of LXRs in the intestine, but not in the liver. This effect is lost in Lxrαß-/- mice. In aggregate, our study identified Enolase as a new target of LXRs in vivo, which may promote cholesterol mobilization for subsequent efflux.
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MEDLINE
Assunto principal:
Fosfopiruvato Hidratase
/
Receptores Nucleares Órfãos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article