Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny.

Lee, W; Johnson, J; Gough, D J; Donoghue, J; Cagnone, G L M; Vaghjiani, V; Brown, K A; Johns, T G; St John, J C

Lee, W; Johnson, J; Gough, D J; Donoghue, J; Cagnone, G L M; Vaghjiani, V; Brown, K A; Johns, T G; St John, J C.

Afiliação

Lee W; 1] Centre for Genetic Diseases, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Johnson J; 1] Centre for Genetic Diseases, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Gough DJ; 1] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Centre for Cancer Research, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Donoghue J; 1] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Centre for Cancer Research, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Cagnone GL; 1] Centre for Genetic Diseases, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Vaghjiani V; 1] Centre for Genetic Diseases, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Brown KA; 1] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Centre for Cancer Research, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Johns TG; 1] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Centre for Cancer Research, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
St John JC; 1] Centre for Genetic Diseases, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.

Cell Death Dis ; 6: e1664, 2015 Feb 26.

Article em En | MEDLINE | ID: mdl-25719248

Assuntos

Metilação de DNA/genética; DNA Mitocondrial/genética; DNA Polimerase Dirigida por DNA/genética; Ácido Ascórbico/farmacologia; Azacitidina/farmacologia; Western Blotting; Diferenciação Celular/efeitos dos fármacos; Diferenciação Celular/genética; Linhagem Celular; Linhagem Celular Tumoral; Imunoprecipitação da Cromatina; Variações do Número de Cópias de DNA/genética; Metilação de DNA/efeitos dos fármacos; DNA Polimerase gama; DNA Polimerase Dirigida por DNA/metabolismo; Humanos; Imunoprecipitação; Reação em Cadeia da Polimerase em Tempo Real

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Metilação de DNA / DNA Polimerase Dirigida por DNA Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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